OVERVIEW

WP 2-Malaria

The Malaria Work Package aims at increasing capacities for the evaluation of new interventions/treatments/vaccines able to further reduce malaria transmission when this is already low, and possibly interrupt it. It is divided in four sub-objectives, each of them translating in several activities.

Objectives

  • To build capacities for the evaluation of new community-based interventions aimed at interrupting malaria transmission in West Africa
  • To build capacities for the evaluation of the efficacy of new insecticides and the monitoring of insecticide resistance
  • To build capacities to determine safety and efficacy of new treatments/vaccines
  • To set up a controlled human malaria infection (CHMI) model in The Gambia, with the aim of conducting early phase trials on new treatments/vaccines. The Gambia has functioning insectaries, culture facilities and excellent clinical facilities where volunteers will be carefully monitored. The CHMI will be “exported” to Senegal pending availability of resources. 

Activities

To build capacities for the evaluation of new community-based interventions aimed at interrupting malaria transmission in West Africa

  • Activity 1: Training in the diagnosis of malaria infections with molecular techniques
  • Activity 2: Training in implementation of community-based cluster randomized trials
  • Activity 3: Training on Malaria-specific trial design and grant writing

To build capacities for the evaluation of the efficacy of new insecticides and the monitoring of insecticide resistance

  • Activity 4: Training on entomological characteristics and profile
  • Activity5: Training on insecticide resistance profile

To setting up a controlled human malaria infection (CHMI) model

  • Activity 6: Setting up the model
  • Activity 7: Exporting the model to other institutions

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